DFS, IPv6 and – sort of – disabling it

Ask the Directory Services Team has a good article on troubleshooting DFS links (DFS Referrals and IPv6: Outta site!) as well as a discussion of how not to  disable IPv6 (unbinding it from an adapter) and how to do it correctly (KB929852).

In case you really need to disable IPv6, consider using a Group Policy Preference or automate it with PowerShell -

Set-ItemProperty HKLM:\SYSTEM\CurrentControlSet\Services\Tcpip6\Parameters DisabledComponents 0xffffffff -type dword

Useful information.